2-Ethoxyethyl acetate

Home Forums Psychedelics 2-Ethoxyethyl acetate

This topic contains 0 replies, has 0 voices, and was last updated by  Megan 7th March 2018 at 4:40 pm.

Viewing 2 posts - 1 through 2 (of 2 total)
  • Author
    Posts
  • #2180

    Megan
    Participant

    General Description

    Synonyms: Cellosolve® acetate; Cellosolve acetate; EGEEA; Ethylene glycol monoethyl ether acetate; Glycol monoethyl ether acetate 

    OSHA IMIS Code Number: 1037

    Chemical Abstracts Service (CAS) Registry Number: 111-15-9

    NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KK8225000

    Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1172 129

    NIOSH Pocket Guide to Chemical Hazards, 2-Ethoxyethyl acetate: chemical description, physical properties, potentially hazardous incompatibilities, and more
    Exposure Limits
    OSHA Permissible Exposure Limit (PEL):

    Quote:
    General Industry: 29 CFR 1910.1000 Table Z-1 — 100 ppm, 540 mg/m3 TWA; Skin 

    Construction Industry: 29 CFR 1926.55 Appendix A — 100 ppm, 540 mg/m3 TWA; Skin

    Maritime: 29 CFR 1915.1000 Table Z-Shipyards — 100 ppm, 540 mg/m3 TWA; Skin

    American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 27 mg/m3 TWA; Skin; BEI 

    National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.5 ppm, 2.7 mg/m3 TWA; Skin
    Health Factors
    NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 500 ppm 

    Potential Symptoms: Irritation of eyes, nose; vomiting; kidney damage; headache, dizziness, drowsiness, paralysis, unconsciousness; in animals: reproductive, teratogenic effects; SKIN ABS; INGES ACUTE: Nausea, vomiting

    Health Effects: Irritation-Eyes, Nose, Throat, Skin—Mild (HE16); Cumulative Blood Disturbances (HE12) Reproductive hazards—Teratogenesis and other reproductive impairment (HE5)

    Affected Organs: Eyes, respiratory system, gastrointestinal tract; reproductive system, hematopoietic system

    Notes:

    1. Explosive vapor/air mixtures of 2-ethoxyethyl acetate may be formed at temperatures above 51°C.
    2. Teratogenic effects in rats by inhalation exposure included heart defects and rib malformations. Increased frequencies of visceral and skeletal variants also occurred. A concentration of 600 ppm was lethal to 100% of the offspring of the 9 pregnant rats exposed to this concentration without the dams showing overt toxicity.
    3. 2-Ethoxyethyl acetate is rapidly hydrolyzed to 2-ethoxyethanol, which in turn, is metabolized mainly by alcohol dehydrogenase to 2-ethoxyacetaldehyde and further by aldehyde dehydrogenase to 2-ethoxyacetic acid, metabolites which are thought to be involved in some of the toxic effects.
    4. Studies of occupational exposure have supported in vitro studies indicating significant systemic absorption of 2-ethoxyethyl acetate through the skin, which measured a mean absorption rate of 0.8 mg per cm2 of human skin per hour.
    5. Curve-fitting of 17 occupationally exposed employees for the time course of urinary excretion of the metabolite, 2-ethoxyacetic acid, yielded an excretion half-time of 57 hours, with individual half-times ranging between 25 and 240 hours.

    Literature Basis:

    • NIOSH Pocket Guide to Chemical Hazards: 2-Ethoxyethyl acetate.
    • International Chemical Safety Cards (WHO/IPCS/ILO): 2-Ethoxyethyl acetate.
    • MMWR: Criteria for a recommended standard: occupational exposure to ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, and their acetates. Morbidity and mortality weekly report 41(21): 386, 1992.
    • Dugard, P.H., Walker, M., Mawdsley, S.J. and Scott, R.C.: Absorption of some glycol ethers through human skin in vitro. Environ. Health Perspect. 57: 193-197, 1984.
    • Johnson, W., Jr., Cosmetic Ingredient Review Expert Panel: Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate. Int. J. Toxicol.21(Suppl. 1): 9-62, 2002.
    • Nelson, B.K., et al.: Comparative inhalation teratogenicity of four glycol ether solvents and an amino derivative in rats. Environ. Health Perspect. 57: 261-271, 1984.
    • Pohanish, R.P. (editor): 2-Ethoxyethyl Acetate. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1037-1039.
    • Söhnlein, B., Letzel, S., Weltle, D., Rüdiger, H.W. and Angerer, J.: Occupational chronic exposure to organic solvents. XIV. Examinations concerning the evaluation of a limit value for 2-ethoxyethanol and 2-ethoxyethyl acetate and the genotoxic effects of these glycol ethers. Int. Arch. Occup. Environ. Health64(7): 479-484, 1993.
    • Stott, W.T. and McKenna, M.J.: Hydrolysis of several glycol ether acetates and acrylate esters by nasal mucosal carboxylesterase in vitro. Fundam. Appl. Toxicol.5(2): 399-404, 1985.
    • Zissu, D.: Experimental study of cutaneous tolerance to glycol ethers. Contact Dermatitis 32(2): 74-77, 1995.

    Date Last Revised: 09/20/2006
    Monitoring Methods used by OSHA
    Primary Laboratory Sampling/Analytical Method (SLC1):

    • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh) 
      analytical solvent: (95:5) Methylene Chloride:Methanol 
      maximum volume: 10 Liters
      maximum flow rate: 0.1 L/min 
      current analytical method: Gas Chromatography; GC/FID 
      method reference: OSHA Analytical Method (OSHA 53) 
      method classification: Fully Validated 
      note: Samples for 2-methoxyethyl acetate and/or for 2-ethoxyethyl acetate should be refrigerated upon receipt at the analytical laboratory.
    • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh) 
      analytical solvent: (95:5) Methylene Chloride:Methanol 
      maximum volume: 48 Liters
      maximum flow rate: 0.1 L/min (long term) 
      maximum volume: 15 Liters
      maximum flow rate: 0.1 L/min (short term) 
      current analytical method: Gas Chromatography; GC/FID 
      method reference: OSHA Analytical Method (OSHA 79) 
      method classification: Fully Validated 
      note: Use these larger maximum volumes to monitor sub-ppm levels. Samples for 2-methoxyethyl acetate and/or for 2-ethoxyethyl acetate should be refrigerated upon receipt at the analytical laboratory.

    Wipe Sampling Method:

    • sampling media: Charcoal pad 
      note: Seal in glass vial for shipment.
    #5216

    Amy
    Participant

    thanol, 2-ethoxy-, acetate; ?-Ethoxyethyl acetate; Cellosolve acetate; Ethyl cellosolve acetate; Ethyl glycol acetate; Ethylene glycol ethyl ether acetate; Glycol monoethyl ether acetate; Oxitol acetate; Poly-Solv EE acetate; 1-Acetoxy-2-ethoxyethane; 2-Ethoxyethanol acetate; 2-Ethoxyethanol, ester with acetic acid; Ethoxyethyl acetate; Ethylene glycol monoethyl ether acetate; Acetate d’ethylglycol; Acetate de cellosolve; Acetate de l’ether monoethylique de l’ethylene-glycol; Acetato di cellosolve; Acetic acid, 2-ethoxyethyl ester; Aethylenglykolaetheracetat; CSAC; Ethyl cellosolve acetaat; Ethylglykolacetat; Octan etoksyetylu; Oxytol acetate; 2-Aethoxy-aethylacetat; 2-Ethoxy-ethylacetaat; 2-Ethoxyethyle, acetate de; 2-Etossietil-acetato; Celosolvacetat; Ektasolve EE acetate solvent; 2-Ethoxyethylester kyseliny octove; Glycol ether EE acetate; UN 1172; 2-Ethoxyethyl ester of acetic acid; Ethoxyethanol acetate; Ethylene glycol monoethyl ether monoacetate; NSC 8658; Cellosove acetate; Ethoxy acetate; ”cellosolve” Acetate; 2-Ethoxy 

Viewing 2 posts - 1 through 2 (of 2 total)

You must be logged in to reply to this topic.