Strychnine

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    Jennifer
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    General Description

    Synonyms: Nux vomica, Strynchnos 

    OSHA IMIS Code Number: 2275

    Chemical Abstracts Service (CAS) Registry Number: 57-24-9

    NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: WL2275000; 79005

    Department of Transportation Regulation Number (49 CFR 172.101) and Guide: UN1692 151 Poison

    NIOSH Pocket Guide to Chemical Hazards, Strychnine: chemical description, physical properties, potentially hazardous incompatibilities, and more 

    Chemical Description and Physical Properties:

    colorless, odorless solid
    molecular weight: 334
    vapor pressure: approx. 0 mm
    boiling point: Decomposes
    melting point: 547°F
    Incompatibilities: Strong oxidizers

    Exposure Limits
    OSHA Permissible Exposure Limit (PEL):

    General Industry: 0.15 mg/m3 

    Construction Industry: 0.15 mg/m3 TWA
    American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.15 mg/m3 TWA

    National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.15 mg/m3 TWA

    Health Factors
    Potential Symptoms: Stiff neck, facial muscles; restlessness, apprehension, increased acuity of perception; increased reflex excitability; cyanosis; tetanic convulsions with opisthotonos 

    Health Effects: Acute systemic toxicity, CNS (Convulsion and Paralysis) (HE4)

    Affected Organs: CNS

    Monitoring Methods used by OSHA
    Primary Laboratory Sampling/Analytical Method (SLC1):

    sampling media: Glass Fiber Filter (37 mm)
    maximum volume: 1000 Liters
    maximum flow rate: 3.0 L/min 
    current analytical method: High Performance Liquid Chromatography; HPLC/UV 
    method reference: 1 (NIOSH 5016)
    method classification: Fully Validated
    Conditions: Column: C18; Mobile Phase: 50:50 Acetonitrile: Water; Detector Wavelength: 254 nm

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