Subtilisins

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    Jennifer
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    General Description:

    Synonyms: Bacillus subtilis; Bacillus subtilis BPN; Bacillus subtilis Carlsburg; Subtilisin BPN; Subtilisin Carlsburg [Note: Commercial proteolytic enzymes are used in laundry detergents.] 

    OSHA IMIS Code Number: 9220 

    Chemical Abstracts Service (CAS) Registry Number: 1395-21-7 (BPN); 9014-01-1 (Carlsburg)

    NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: CO9450000 (BPN); CO9550000 (Carlsburg) 

    NIOSH Pocket Guide to Chemical Hazards, Subtilisins: chemical description, physical properties, potentially hazardous incompatibilities, and more

    Exposure Limits
    American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.00006 mg/m3 Ceiling (Listed under Subtilisins, as crystalline active enzyme)

    National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.00006 mg/m3 STEL (60 Minutes)

    Health Factors
    Health Effects: Respiratory allergy (asthma) (HE9); Lung damage (HE10); Irritation-Skin—Mild (HE16)

    Monitoring Methods used by OSHA
    Bulk Method:

    Submit 1 gram pure bulk material.
    note: The only analysis for Subtilisins currently performed at the Salt Lake Technical Center is its content in bulk material samples. OSHA staff should call the Salt Lake Technical Center for guidance.

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